Dissolution improvement of binary solid dispersions of Carbamazepine using Poly (2-ethyl-2-oxazoline) as the hydrophilic copyright

Dissolution improvement of binary solid dispersions of Carbamazepine using Poly (2-ethyl-2-oxazoline) as the hydrophilic copyright

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The aim of this study was to design and fine mic evaluate the properties of solid dispersions of carbamazepine (CBZ) using poly (2-ethyl-2-oxazoline) (POX) as the hydrophilic copyright.These binary solid dispersions were prepared at varying drug loadings using the solvent evaporation method.The samples were evaluated for their in vitro 12n/1200 wella dissolution, and solid-state properties.There was over 350% increase in dissolution rate of CBZ in samples containing at least 50% POX.

This study concludes that POX is an effective hydrophilic copyright for poorly soluble drugs in solid dispersions.